Regulation of eukaryotic gene expression by transcriptional attenuation.
نویسندگان
چکیده
منابع مشابه
Regulation of eukaryotic gene expression by transcriptional attenuation.
The regulation of transcriptional elongation and termination is well documented as a means of controlling the expression of prokaryotic genes, and molecular and genetic analysis has yielded a clear understanding of the diverse mechanisms involved (reviewed in Yanofsky, 1988; Spencer and Groudine, 1990; Kerppola and Kane, 1991). It is now evident that the expression of several eukaryotic viral a...
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5-mer peptide MVKTD, we demonstrate a correlation between the in vitro antipeptidyltransferase activity and the ability of the same peptide to support induction by chloramphenicol in vivo. MVKTD footprints to nucleotides 2058, 2059, and 2060 in 23S rRNA. In vivo methylation of nucleotide .2058 by the ernC methylase interferes neither with cat-86 induction nor with peptide inhibition of peptidyl...
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Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...
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Cystic Fibrosis results from mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The gene was identified in 1989, but more than 20 years later, the regulatory mechanisms controlling its complex expression are still not fully understood. Though the promoter binds transcription factors and drives some aspects of CFTR gene expression, it cannot alone account for tissue...
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Recent structure determinations of high order complexes of eukaryotic transcription factors bound to DNA have revealed that residues from their DNA-binding domains are involved in protein-protein interactions between distinct factors. Protein-protein interactions between transactivation domains and coactivators have also been characterized in a number of recently determined structures. These st...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1993
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.4.7.661